HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → HCID 22479013, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | tert-Butyl (4-((3-aminoquinolin-4-yl)amino)butyl)carbamate | HCID 18783942 | — |
| Product | HCID 22479013 | HCID 22479013 | — |
Reaction Steps
Using the general method of Example 1 Part C, tert-butyl N-(4-[(3-aminoquinolin-4-yl)amino]butyl)carbamate (149 g, 0.451 mol) was reacted with triethyl orthoformate to provide crude product. This material was recrystallized from isopropyl alcohol to provide 84 g of tert-butyl N-[4-(1H-imidazo[4,5-c]quinolin-1-yl)butyl]carbamate as a crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157453B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-b304bd358d8d41c6ae62739c10bf504d |
| Source note | uspto-grants-2007_01 |