4-Morpholinecarbonyl chloride → HCID 10339032, compound

Participants

Reaction Steps

Using the general method of Example 150 except that the reaction was run at 0° C., 1-(3-aminopropyl)-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine (2.0 g, 7.8 mmol) was reacted with 4-morpholinecarbonyl chloride (1.17 g, 7.8 mmol) to provide 1.35 g of N-[3-(4-amino-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]morpholine-4-carboxamide as a white solid, m.p. 226.0–228.0° C. Analysis: Calculated for C19H24N6O2: % C, 61.94; % H, 6.57; % N, 22.81; Found: % C, 61.67; % H, 6.46; % N, 22.74.

Provenance & Evidence