HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide → N-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide | HCID 2734619 | — |
| Reactant | 3-Bromo-N-cyclopropylimidazo[1,2-a]pyrazin-8-amine | HCID 21070912 | — |
| Product | N-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-acetamide | HCID 21070830 | 12% |
Reaction Steps
Using Method 2, the title compound was prepared in 12% yield from 3-bromo-imidazo[1,2-a]pyrazin-8-yl)-cyclopropyl-amine (Example 6) and N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetamide (from Aldrich).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157460B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-2eae08511ce64c79bdf7ed4994ac1fb0 |
| Source note | uspto-grants-2007_01 |