Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl- → N-Methylimidazo[1,2-A]pyrazin-8-amine

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Reaction Steps

To a solution of (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine (Example 1) (2.4 g, 11.9 mmol) in methanol (160 ml) was added Pd-C (10% wt. 0.1 eq). The mixture was hydrogenated at rt overnight, filtered, and washed with hot methanol. The organics were combined and concentrated to afford 2.8 g of crude imidazo[1,2-a]pyrazin-8-yl-methyl-amine (M).

Provenance & Evidence