Ammonia → tert-Butyl 2-[({[(4-chlorophenyl)amino]carbonyl}amino)methyl]morpholine-4-carboxylate

Participants

Reaction Steps

To a stirred solution of tert-butyl 2-(aminomethyl)morpholine-4-carboxylate (Prepared as described in EP 0 468231, 2.4 g) in dichloromethane (100 ml) was added 4-chlorophenylisocyanate (1.87 g). The mixture was stirred at 22° C. for 16 h before 10% 0.880 ammonia solution in methanol was added. Stirring was continued for a further 30 min before the solvent was removed in vacuo to give the title compound as a white foam (3.98 g).

Provenance & Evidence