tert-Butyl 2-[({[(4-chlorophenyl)amino]carbonyl}amino)methyl]morpholine-4-carboxylate → N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

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Reaction Steps

Intermediate 8 (1.9 g) was stirred in 4.0M hydrogen chloride in 1,4-dioxane (40 ml) at 22° C. for 30 min. The solvent was removed in vacuo and the residue was purified by solid phase extraction (Isolute SCX sulphonic acid column), eluting with methanol followed by 10% 0.880 NH3 solution in methanol, to give the title compound as a cream foam (1.15 g). LC/MS (System A) Rt 2.03 min, Mass Spectrum m/z 270 [MH+].

Provenance & Evidence