HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-{[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}butanoate → 4-{[({[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}butanoic Acid Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-{[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}butanoate | HCID 86760343 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-{[({[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}butanoic Acid Hydrochloride | HCID 69507153 | 199.8% |
Reaction Steps
Intermediate 25 (0.345 g) was dissolved in 4M hydrogen chloride in dioxane (5 ml), and the mixture was allowed to stand at 22° C. for 19.5 h. The solvent was evaporated in vacuo to give the title compound as a white solid (0.330 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-e8ccaa3a493b4a3d979e63254994d5dc |
| Source note | uspto-grants-2007_01 |