Acetic Anhydride → N-[3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-acetamide

HRID 13714Notes

Reaction equation

HRID 13714 reaction equation
[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH2:22])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH:22][C:23](=[O:25])[CH3:24])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 589417073-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

Product 1

HCID 58941705N-[3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-acetamide

Procedure

Utilizing 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine and acetic anhydride, the title compound is prepared as in example 15. 0.16 g (46%). LC-MS m/z 337.1 (M++1).

Sources & evidence

ORD record
ord-891387ccf64a4bf583c88ab97bfea1c7
Source dataset
uspto-grants-2010_06
Patent number
US07728150B2

Reaction notes

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