3-Bromophenyl isocyanate → HCID 10299060, compound

HRID 1371412Notes

Reaction equation

HRID 1371412 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([N:25]=[C:26]=[O:27])[CH:20]=1>>[Br:18][C:19]1[CH:20]=[C:21]([NH:25][C:26]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:27])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 1410013-Bromophenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10299060HCID 10299060, compound

Procedure

Example 12 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-bromo-3-isocyanatobenzene (17.0 μl) to give the title compound (0.03 g). LC-MS (System A): Rt 2.50 mins, Mass Spectrum m/z 472 [MH+].

Workup

  1. customExample 12 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-b80cc3e7ef8a4f6d9f8b8e39af0a8a14
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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