4-(Difluoromethoxy)phenyl isocyanate → HCID 17984679, compound

HRID 1371416Notes

Reaction equation

HRID 1371416 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][CH:19]([F:30])[O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:28]([NH:27][C:24]2[CH:23]=[CH:22][C:21]([O:20][CH:19]([F:18])[F:30])=[CH:26][CH:25]=2)=[O:29])[CH2:7]1

Participants

3

Reactant 2

HCID 27333714-(Difluoromethoxy)phenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 17984679HCID 17984679, compound

Procedure

Example 16 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-(difluoromethoxy)-4-isocyanatobenzene (19.1 μl) to give the title compound (0.0252 g). LC-MS (System A): Rt 2.41 mins, Mass Spectrum m/z 460 [MH+].

Workup

  1. customExample 16 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-3988cfa2f2384b05bf15034deec4d81c
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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