4-Fluorophenyl isocyanate → HCID 17984752, compound

HRID 1371417Notes

Reaction equation

HRID 1371417 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:26]([NH:25][C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=2)=[O:27])[CH2:7]1

Participants

3

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 17984752HCID 17984752, compound

Procedure

Example 17 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-fluoro-4-isocyanatobenzene (15.5 μl) to give the title compound (0.031 μg). LC-MS (System A): Rt 2.30 mins, Mass Spectrum m/z 421 [MH+].

Workup

  1. customExample 17 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-b2c45354be374b7eb52bdbc998d7c87a
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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