1-(Bromomethyl)-3-chlorobenzene → HCID 10111206, compound

HRID 1371425Notes

Reaction equation

HRID 1371425 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.Br[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=1>>[Cl:27][C:23]1[CH:22]=[C:21]([CH:26]=[CH:25][CH:24]=1)[CH2:20][N:15]1[CH2:16][CH2:17][O:18][CH:13]([CH2:12][NH:11][C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:10])[CH2:14]1

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 23089254N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

Product 1

HCID 10111206HCID 10111206, compound

Procedure

Example 26 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and 1-(bromomethyl)-3-chlorobenzene (5.4 μl) to give the title compound (0.0023 g). LC-MS (System A): Rt 2.72 mins, Mass Spectrum m/z 394 [MH+].

Workup

  1. customExample 26 was prepared in an analogous manner to Example 19 using

Sources & evidence

ORD record
ord-17d08f4289b44ccba9e89ae1ad3e12f3
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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