4-Phenylbenzyl chloride → HCID 10113871, compound

HRID 1371427Notes

Reaction equation

HRID 1371427 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.Cl[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:23][CH:22]=1>>[C:24]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:23]=[CH:22][C:21]([CH2:20][N:15]2[CH2:16][CH2:17][O:18][CH:13]([CH2:12][NH:11][C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:10])[CH2:14]2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 154634-Phenylbenzyl chlorideHCID 23089254N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

Product 1

HCID 10113871HCID 10113871, compoundYield 32.2%

Procedure

Example 30 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and 4-(chloromethyl)-1,1′-biphenyl (0.0083 g) to give the title compound (0.0052 g). LC-MS (System A): Rt 2.95 mins, Mass Spectrum m/z 436 [MH+].

Workup

  1. customExample 30 was prepared in an analogous manner to Example 19 using

Sources & evidence

ORD record
ord-dcb6968134fb4b17947aa36db9e1beb4
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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