4-Phenoxyphenyl isocyanate → HCID 10140977, compound

HRID 1371430Notes

Reaction equation

HRID 1371430 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[CH:23][CH:22]=2)=[O:20])[CH2:7]1

Participants

3

Reactant 2

HCID 27348964-Phenoxyphenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10140977HCID 10140977, compound

Procedure

Example 33 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-isocyanato-4-phenoxybenzene (24.6 μl) to give the title compound (0.0171 g). LC-MS (System A): Rt 2.62 mins, Mass Spectrum m/z 486 [MH+].

Workup

  1. customExample 33 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-00948dfe75f24c4896afaa06fef666d8
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

Loading…