1-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzene → HCID 10228414, compound

HRID 1371431Notes

Reaction equation

HRID 1371431 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:26]=[CH:25][C:24]([S:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[CH:26]=[CH:25][C:24]([S:27][C:28]([F:30])([F:29])[F:31])=[CH:23][CH:22]=2)=[O:20])[CH2:7]1

Participants

3

Reactant 2

HCID 27333921-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzeneHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10228414HCID 10228414, compound

Procedure

Example 34 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-isocyanato-4-[(trifluoromethyl)thio]benzene (21.9 μl) to give the title compound (0.0122 g). LC-MS (System A): Rt 2.70 mins, Mass Spectrum m/z 494 [MH+].

Workup

  1. customExample 34 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-5aef835369ba4cf7adcb835022ec2aeb
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

Loading…