1-(2-Bromoethoxy)-4-fluorobenzene → HCID 10223131, compound

HRID 1371437Notes

Reaction equation

HRID 1371437 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.Br[CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][N:15]([CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH2:14]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 23089254N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

Product 1

HCID 10223131HCID 10223131, compoundYield 46.3%

Procedure

Example 40 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and 1-(2-bromoethoxy)-4-fluorobenzene (0.0089 g) to give the title compound (0.007 g). LC-MS (System A): Rt 2.69 mins, Mass Spectrum m/z 408 [MH+].

Workup

  1. customExample 40 was prepared in an analogous manner to Example 19 using

Sources & evidence

ORD record
ord-d69af6c8ccf94f89aca08db3b0ddba9b
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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