3-Acetamidobenzylamine → HCID 69507141, compound

HRID 1371443Notes

Reaction equation

HRID 1371443 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14](=[O:25])[O:15]C2C=CC([N+]([O-])=O)=CC=2)[CH2:7]1.[C:30]([NH:33][C:34]1[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=1)[CH2:37][NH2:38])(=[O:32])[CH3:31]>>[CH:14]([OH:25])=[O:15].[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14]([NH:38][CH2:37][C:36]2[CH:35]=[C:34]([NH:33][C:30](=[O:32])[CH3:31])[CH:41]=[CH:40][CH:39]=2)=[O:25])[CH2:7]1

Participants

3

Reactant 2

HCID 27609463-AcetamidobenzylamineHCID 115394484-Nitrophenyl [4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate

Product 1

HCID 69507141HCID 69507141, compoundYield 34.4%

Procedure

Example 52 was prepared in an analogous manner to Example 43 from Intermediate 10 (0.04 g) and 3-acetamidobenzylamine (0.022 g), and purified by Mass Directed Automated Preparative HPLC to yield the title compound (0.008 g).

Workup

  1. custompurified by Mass Directed Automated Preparative HPLC

Sources & evidence

ORD record
ord-e0f66619635946cd82c4e3e4b10e6afa
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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