HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminomethyl)benzamide → 4-({[({[(2R)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminomethyl)benzamide | HCID 2512818 | — |
| Reactant | 4-Nitrophenyl [(2R)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate | HCID 86760342 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-({[({[(2R)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)benzamide | HCID 9825034 | 74.1% |
Reaction Steps
Example 55 was prepared in an analogous manner to Example 43 from Intermediate 14 (0.109 g) and 4-aminomethylbenzamide (0.045 g) using N,N-dimethylformamide as solvent to yield the title compound (0.0828 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-acd419e2322849849068584106ccd3ad |
| Source note | uspto-grants-2007_01 |