HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → N-{[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-prop-2-ynylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Reactant | 4-Nitrophenyl [(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate | HCID 11775024 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-{[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-prop-2-ynylurea | HCID 9968600 | 79.1% |
Reaction Steps
Example 57 was prepared in an analogous manner to Example 43 from Intermediate 13 (0.1 g) and propargylamine (0.014 g) using dichloromethane and triethylamine at a temperature of 22° C. to yield the title compound (0.064 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-bbcdf3fd5ef746529ddfeb67a1ec34e8 |
| Source note | uspto-grants-2007_01 |