HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → N-{[(2R)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-prop-2-ynylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Reactant | 4-Nitrophenyl [(2R)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate | HCID 86760342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-{[(2R)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-prop-2-ynylurea | HCID 10108908 | 62.9% |
Reaction Steps
Example 58 was prepared in an analogous manner to Example 43 from Intermediate 14 (0.12 g) and propargylamine (0.014 g) using dichloromethane and triethylamine at a temperature of 22° C. to yield the title compound (0.057 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-2c7169097a404ca1a20fb7c320611899 |
| Source note | uspto-grants-2007_01 |