Butylamine → 2-Butylaminoadenine

HRID 1371464Notes

Reaction equation

HRID 1371464 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 949042-Chloroadenine

Product 1

HCID 34879632-Butylaminoadenine

Procedure

2-Chloroadenine (6.0 g, 35.4 mmol) and butylamine (30 ml) were placed in an autoclave (200 ml), and the content of the autoclave was allowed to react at 130° C. for 150 hours. The reaction solution was concentrated under reduced pressure, and water was poured into the residue to precipitate a solid. The precipitated solid was sequentially washed with methylene chloride and methanol. Thus, 2.08 g of the title compound was obtained as a yellowish orange powdery solid (yield: 30%).

Workup

  1. customto react at 130° C. for 150 hours
  2. concentrationThe reaction solution was concentrated under reduced pressure, and water
  3. additionwas poured into the residue
  4. customto precipitate a solid
  5. washThe precipitated solid was sequentially washed with methylene chloride and methanol

Sources & evidence

ORD record
ord-d44423b74b914ebda6f8308c6b480c7d
Source dataset
uspto-grants-2007_01
Patent number
US07157465B2

Reaction notes

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