反应详情

2-Chloroadenine (6.0 g, 35.4 mmol) and butylamine (30 ml) were placed in an autoclave (200 ml), and the content of the autoclave was allowed to react at 130° C. for 150 hours. The reaction solution was concentrated under reduced pressure, and water was poured into the residue to precipitate a solid. The precipitated solid was sequentially washed with methylene chloride and methanol. Thus, 2.08 g of the title compound was obtained as a yellowish orange powdery solid (yield: 30%).

1. customto react at 130° C. for 150 hours
2. concentrationThe reaction solution was concentrated under reduced pressure, and water
3. additionwas poured into the residue
4. customto precipitate a solid
5. washThe precipitated solid was sequentially washed with methylene chloride and methanol