Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-Methyl-2-piperidone | HCID 13603 | — |
| 반응물 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 반응물 | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine | HCID 21262765 | 86.9% |
반응 단계
21.5 g 2,5-difluoro-nitrobenzene, 52.3 g 1-benzyl-4-amino-piperidine and 100 ml N-methyl-piperidone were stirred at 100° C. for 3 h. After cooling the mixture was treated distributed between water and ethyl acetate and the aqeous layer was extracted 2× with ethyl acteate. The combined organic layers were extracted 5× with water, and the solvent was removed by evaporation. The target compound was crystallized from methanol to yield 38.7 g orange crystals (mp. 86–87° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07157471B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-8dbf4e731685405d87021e7dd2486338 |
| 출처 메모 | uspto-grants-2007_01 |