HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | 1-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine | HCID 21262765 | — |
| Katalysator | Platinum | HCID 23939 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine | HCID 21193065 | 99,1% |
Reaktionsschritte
10.1 g 1-Benzyl-4-(4-fluoro-2-nitro-phenylamino)-piperidine were dissolved in 75 ml THF and 75 ml methanol and hydrogenated with 1.5 g Pt/C (10%). The catalyst was filtered, and the filtrate was evaporated to yield 9.1 g of the target compound as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07157471B2 |
| Quelldatensatz | uspto-grants-2007_01 |
| ORD ID | ord-75336fe606ce4ac4a808dac1ce0bf69d |
| Quellennotiz | uspto-grants-2007_01 |