HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 21070948, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | tert-Butyl 4-(isoquinolin-5-yl)piperazine-1-carboxylate | HCID 21070949 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Product | HCID 21070948 | HCID 21070948 | 30% |
Reaction Steps
The compound of Step 2 (200 mg, 0.64 mmol) is dissolved in absolute ethanol (50 mL), and Pt/C 10% catalyst (200 mg) is added. The mixture is pressurized to 45 psi under hydrogen and shaken for about 4 hours at r.t. The mixture is filtered over celite, concentrated and chromatographed on silica gel to give about 68 mg of 5-(4-t-butyloxycarbonylpiperazin-1-yl)-2-ethyl-1,2,3,4-tetrahydroisoquinoline (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157463B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-e90df2d3e1da4592a1081be2e80cc82e |
| Source note | uspto-grants-2007_01 |