HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1371531Generated: November 2, 2026
Malonic Acid → 3-amino-3-(3-methylphenyl)propanoic acid
https://huagongshe.com/reaction/1371531
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 3-Methylbenzaldehyde | HCID 12105 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 3-amino-3-(3-methylphenyl)propanoic acid | HCID 2764298 | — |
Reaction Steps
11.8 ml of 3-methylbenzaldehyde are added to a mixture of 10.4 g of malonic acid and 15.4 g of ammonium acetate in 150 ml of 2-methoxyethanol, and the mixture is heated overnight at 80° C. After cooling to RT, the precipitate formed is filtered off under suction, washed with ether and dried. 6.8 g of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07157454B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-5a501653de8a4fa78aac7f124847d97a |
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| Source note | uspto-grants-2007_01 |
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