HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-amino-3-(2,3-dihydro-1,4-benzodioxin-6-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde | HCID 248127 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-amino-3-(2,3-dihydro-1,4-benzodioxin-6-yl)propanoic acid | HCID 3536450 | 28.9% |
Reaction Steps
A mixture of 5 g of 2,3-dihydrobenzo[1,4]dioxine-6-carbaldehyde, 3.17 g of malonic acid and 4.69 g of ammonium acetate in 50 ml of EtOH is refluxed for 5 hours. The reaction mixture is allowed to cool to RT and the precipitate formed is filtered off by suction and washed with EtOH and then with water. 1.965 g of the expected product are obtained after drying under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157454B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-24aa4dc4f9044169ba58e0a9c056c3b4 |
| Source note | uspto-grants-2007_01 |