Ethanol → HCID 11676934, compound

Participants

Reaction Steps

N-Trifluoroacetyl-4-(5-(3-(3-chloro-propoxy)-phenylacetyl)amino-[1,3,4]thiadiazol-2-yl)-furazan-3-ylamine (0.05 g, 0.1 mmol), 4-amino-N-Boc-piperidine (0.082 g, 0.4 mmol) and EtOH (0.3 mL) were heated by microwave irradiation at 120° C., 10 minutes; 150° C., 10 minutes; and 150° C., 30 minutes. The reaction was diluted with water and purified by preparative HPLC. Yield: 0.02 g (43%). 1H-NMR (MeOD) δ 7.27–7.30 (t, 1H), 6.96–6.98 (m, 2H), 6.88 (d, 1H), 4.14 (t, 2H), 3.87 (s, 2H), 3.50–3.60 (m, 3H), 3.07–3.10 (m, 2H), 2.36–2.39 (m, 2H), 2.17–2.20 (m, 2H), 1.82–1.90 (m, 2H), 1.30–1.35 (m, 2H). LCMS 459.0 (M+1), HPLC Method B Rt 1.7 minutes.

Provenance & Evidence