Chloroacetone → HCID 11615485, compound

Participants

Reaction Steps

A mixture of 4-amino-N-isobutyl-1,2,5-oxadiazole-3-carboxamidine (38 mg, 0.2 mmol), 1-chloropropanone (37 mg, 0.4 mmol) and potassium carbonate (55 mg, 0.4 mmol) in DMF (0.5 mL) was microwaved for 20 minutes at 180° C. The crude mixture was purified via Gilson and then a flash pipette column to afford the title compound as a white solid 2.5 mg. HPLC Rt 5.6 min; MS 222.1 as M+1 peak; HPLC Method B Rt 3.4 min. 1HNMR (CDCl3) 6.94 (s, 1H); 5.73 (br, 2H); 4.15 (d, 2H); 2.3 (s, 3H); 2.15 (m, 1H); 0.95 (d, 6H).

Provenance & Evidence