HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2,6-difluorobenzene → HCID 11974837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2,6-difluorobenzene | HCID 123557 | — |
| Reactant | 5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl- | HCID 11974832 | — |
| Reactant | HCID 178506757 | HCID 178506757 | — |
| Product | HCID 11974837 | HCID 11974837 | 70% |
Reaction Steps
The same procedure was used as described in Example 2, starting from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methylamide (200 mg, 0.830 mmol, Example 1) and a solution of 2,6-difluorophenyl lithium (˜3 equiv, freshly prepared from 1-bromo-2,6-difluorobenzene (Aldrich), as in Example 2A), to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-phenyl)-methanone as a white solid (170 mg, 70% yield). HRMS, observed: 296.0667; Calcd for (M+H)+: 296.0664.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157455B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-6d47301c7bf84fdf9068291382155aeb |
| Source note | uspto-grants-2007_01 |