Benzenesulfonyl chloride → N-[3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-benzenesulfonamide

HRID 13716Notes

Reaction equation

HRID 13716 reaction equation
[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH2:22])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[C:23]1([S:29](Cl)(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH:22][S:29]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)(=[O:31])=[O:30])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 589417073-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

Product 1

HCID 58941682N-[3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-benzenesulfonamide

Procedure

Utilizing 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine and benzenesulfonyl chloride, the title compound is prepared as in example 15. 0.21 g (33%). LC-MS m/z 295.1 (M++1).

Sources & evidence

ORD record
ord-cf1ee4e6db4a448696a3fcdc043f046f
Source dataset
uspto-grants-2010_06
Patent number
US07728150B2

Reaction notes

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