Isobutyl chloroformate → 4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid iso-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Isobutyl chloroformate	HCID 62365	—
Reactant	[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt	HCID 69014044	—
Product	4-[4-Amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid iso-butyl ester	HCID 10071185	—

Reaction Steps

The same procedure as described in Example 17 was used, starting from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2-methoxy-phenyl)-methanone trifluoroacetic acid salt, Example 11, and isobutyl chloroformate (Aldrich), to afford 4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid iso-butyl ester. HRMS, observed: 428.2295; Calcd for (M+H)+: 428.2293

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07157455B2
Source dataset	uspto-grants-2007_01
ORD ID	ord-d75b7c33f0db4e07b8700fbc6290a453
Source note	uspto-grants-2007_01