1-BOC-3-Aminopiperidine → HCID 58777573, compound

HRID 1371615Notes

Reaction equation

HRID 1371615 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[O:9])=[CH:6][N:5]=[C:4](S(CC)(=O)=O)[N:3]=1.[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][CH2:33][CH:32]([NH2:36])[CH2:31]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][CH2:33][CH:32]([NH:36][C:4]2[N:3]=[C:2]([NH2:1])[C:7]([C:8](=[O:9])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[O:16][CH3:17])=[CH:6][N:5]=2)[CH2:31]1)=[O:29])([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 5458091-BOC-3-AminopiperidineHCID 11961965(4-Amino-2-ethanesulfonylpyrimidin-5-yl)-(2-methoxyphenyl)-methanone

Product 1

HCID 58777573HCID 58777573, compound

Procedure

The same procedure was used as described in Example 9 starting from (4-amino-2-ethanesulfonylpyrimidin-5-yl)-(2-methoxyphenyl)-methanone, Example 6, and 3-amino-piperidine-1-carboxylic acid tert-butyl ester (Astatech) to give 3-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester. MS (M+H)+, 428.

Sources & evidence

ORD record
ord-352150825f944fd8907446c26ebda919
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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