Ethyl chloroformate → HCID 58777667, compound

HRID 1371629Notes

Reaction equation

FC(F)(F)C(O)=O.[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13][N:12]=[C:11]([NH:26][C@@H:27]2[CH2:31][CH2:30][NH:29][CH2:28]2)[N:10]=1.Cl[C:33]([O:35][CH2:36][CH3:37])=[O:34]>>[CH2:36]([O:35][C:33]([N:29]1[CH2:30][CH2:31][C@@H:27]([NH:26][C:11]2[N:10]=[C:9]([NH2:8])[C:14]([C:15](=[O:16])[C:17]3[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=3[O:24][CH3:25])=[CH:13][N:12]=2)[CH2:28]1)=[O:34])[CH3:37]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 69016193(r)-[4-Amino-2-(pyrrolidin-3-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt

Product 1

HCID 58777667HCID 58777667, compound

Procedure

The same procedure as described in Example 60 was used, starting from (R)-[4-amino-2-(pyrrolidin-3-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt, Example 70, and ethyl chloroformate (Aldrich) to give (R)-3-[4-amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-pyrrolidine-1-carboxylic acid ethyl ester. MS (M+H)+, 404.

Sources & evidence

ORD record: ord-874cce934a024b5c8263d1f0a0d96d44
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157455B2

Reaction notes

Loading…