1-Bromo-4,5-difluoro-2-methoxybenzene → HCID 11723824, compound

HRID 1371643Notes

Reaction equation

HRID 1371643 reaction equation
COCN[C:5]([C:7]1[C:8]([NH2:16])=[N:9][C:10]([S:13][CH2:14][CH3:15])=[N:11][CH:12]=1)=[O:6].Br[C:18]1[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:19]=1[O:26][CH3:27]>>[NH2:16][C:8]1[C:7]([C:5]([C:20]2[C:19]([O:26][CH3:27])=[CH:18][CH:23]=[C:22]([F:24])[C:21]=2[F:25])=[O:6])=[CH:12][N:11]=[C:10]([S:13][CH2:14][CH3:15])[N:9]=1

Participants

3

Reactant 2

HCID 27362621-Bromo-4,5-difluoro-2-methoxybenzeneHCID 101057874-Amino-2-ethylsulfanylpyrimidine-5-carboxylic acid methoxymethylamide

Product 1

HCID 11723824HCID 11723824, compound

Procedure

The same procedure as described in Example 47 was used, starting from 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid methoxymethylamide, Example 1, and 2-bromo-4,5-difluoro-anisole (Astatech), to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone as a white solid. MS (M+H)+, 326.

Sources & evidence

ORD record
ord-991c4bcd91d54a04bb74158661b0668e
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

Loading…