Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 11975080 | HCID 11975080 | — |
| Reactant | N-(4-aminocyclohexyl)methanesulfonamide | HCID 18348422 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178491849 | HCID 178491849 | — |
Reaction Steps
To a stirred solution of N-(4-amino-cyclohexyl)-methanesulfonamide, Example 122, (211 mg, 0.69 mmol) in dimethylformamide, triethylamine (40 μL, 2.87 mmol) and the compound of Example 103 (200 mg, 0.57 mmol) were added and the mixture was stirred at 90° C. for 1 hour. Then the mixture was poured into water and extracted with ethyl acetate, dried (sodium sulfate) and concentrated. The residue was chromatographed to give the product. 185 mg, 71%. MS(ES) (M+H)+=456.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07157455B2 |
|---|
| Source dataset | uspto-grants-2007_01 |
|---|
| ORD ID | ord-459a656e2fdd4fffb9da836ecac1f1aa |
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| Source note | uspto-grants-2007_01 |
|---|
