2-Bromo-1-ethoxy-4-fluorobenzene → (4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-(2-ethoxy-5-fluoro-phenyl)-methanone

HRID 1371679Notes

Reaction equation

HRID 1371679 reaction equation
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13]C)=[N:10][CH:11]=1)=[O:5].Br[C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1[O:25][CH2:26][CH3:27]>>[NH2:15][C:7]1[C:6]([C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25][CH2:26][CH3:27])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1

Participants

3

Reactant 2

HCID 106326422-Bromo-1-ethoxy-4-fluorobenzeneHCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-

Product 1

HCID 21070609(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-(2-ethoxy-5-fluoro-phenyl)-methanone

Procedure

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2-bromo-1-ethoxy-4-fluoro-benzene (prepared from 2-bromo-4-fluoro-phenol, Aldrich) in an analogous manner as described in Example 169.

Sources & evidence

ORD record
ord-8422e217b12a4c7f8b72146c278068c9
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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