5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl- → HCID 21070610, compound

HRID 1371680Notes

Reaction equation

HRID 1371680 reaction equation
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13]C)=[N:10][CH:11]=1)=[O:5].Br[C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1[CH2:25][CH3:26]>>[NH2:15][C:7]1[C:6]([C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[CH2:25][CH3:26])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1

Participants

3

Reactant 2

HCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 22572751HCID 22572751, compound

Product 1

HCID 21070610HCID 21070610, compound

Procedure

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2-bromo-1-ethyl-4-fluoro-benzene (prepared from 2-bromo-4-fluoroacetophenone, WO0015634) in an analogous manner as described in Example 169.

Sources & evidence

ORD record
ord-42e322c34ae14b7b923ba8539aba3ea3
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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