[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 10479319, compound

HRID 1371683Notes

Reaction equation

HRID 1371683 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][C:13]([F:18])=[C:12]([F:19])[C:11]=2[F:20])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:32][S:33]([N:36]1[CH2:41][CH2:40][CH:39]([NH2:42])[CH2:38][CH2:37]1)(=[O:35])=[O:34]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][C:13]([F:18])=[C:12]([F:19])[C:11]=2[F:20])=[O:9])=[CH:6][N:5]=[C:4]([NH:42][CH:39]2[CH2:40][CH2:41][N:36]([S:33]([CH3:32])(=[O:35])=[O:34])[CH2:37][CH2:38]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070553HCID 21070553, compound

Product 1

HCID 10479319HCID 10479319, compound

Procedure

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(2,3,4-trifluoro-6-methoxy-phenyl)-methanone (Example 194) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C18H21N5O4SF3 [(M+H)+] 460.1261, observed 460.1267. CDK4 IC50=0.001; CDK1 IC50=0.005; CDK2 IC50=0.002; HCT 116 IC90=0.630 μM.

Sources & evidence

ORD record
ord-6bcb965ce5fc498287866712852beabd
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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