[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [4-Amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-isopropoxy-phenyl)-methanone

HRID 1371688Notes

Reaction equation

HRID 1371688 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH:18]([CH3:20])[CH3:19])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:32][S:33]([N:36]1[CH2:41][CH2:40][CH:39]([NH2:42])[CH2:38][CH2:37]1)(=[O:35])=[O:34]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH:18]([CH3:19])[CH3:20])=[O:9])=[CH:6][N:5]=[C:4]([NH:42][CH:39]2[CH2:40][CH2:41][N:36]([S:33]([CH3:32])(=[O:35])=[O:34])[CH2:37][CH2:38]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070600HCID 21070600, compound

Product 1

HCID 10072504[4-Amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-isopropoxy-phenyl)-methanone

Procedure

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(5-fluoro-2-isopropoxy-phenyl)-methanone (Example 200) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C20H27N5O4SF [(M+H)+] 452.1766, observed 452.1766.

Sources & evidence

ORD record
ord-01aa0c58e8474c81947ebcf1e0d03bec
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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