[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 10455752, compound

HRID 1371689Notes

Reaction equation

HRID 1371689 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH2:18][CH3:19])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:31][S:32]([N:35]1[CH2:40][CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]1)(=[O:34])=[O:33]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH2:18][CH3:19])=[O:9])=[CH:6][N:5]=[C:4]([NH:41][CH:38]2[CH2:39][CH2:40][N:35]([S:32]([CH3:31])(=[O:34])=[O:33])[CH2:36][CH2:37]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070594HCID 21070594, compound

Product 1

HCID 10455752HCID 10455752, compound

Procedure

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(2-ethoxy-5-fluoro-phenyl)-methanone (Example 201) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C19H25N5O4SF [(M+H)+] 438.1606, observed 438.1610.

Sources & evidence

ORD record
ord-bb40c1e662b2488596bad3af431df3ab
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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