[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 10027817, compound

HRID 1371691Notes

Reaction equation

HRID 1371691 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[O:20][CH3:21])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:33][S:34]([N:37]1[CH2:42][CH2:41][CH:40]([NH2:43])[CH2:39][CH2:38]1)(=[O:36])=[O:35]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:17])([F:19])[F:18])=[CH:12][C:11]=2[O:20][CH3:21])=[O:9])=[CH:6][N:5]=[C:4]([NH:43][CH:40]2[CH2:41][CH2:42][N:37]([S:34]([CH3:33])(=[O:36])=[O:35])[CH2:38][CH2:39]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070596HCID 21070596, compound

Product 1

HCID 10027817HCID 10027817, compound

Procedure

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(2-methoxy-4-trifluoromethyl-phenyl)-methanone (Example 203) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C19H23N5O4SF3 [(M+H)+] 474.1418, observed 474.1418.

Sources & evidence

ORD record
ord-d67de29f61e74b94b72856fe160f7923
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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