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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1371694Generated: November 1, 2026

1-Methylpiperazine → HCID 10030866, compound

https://huagongshe.com/reaction/1371694

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanoneHCID 9983584—
ProductHCID 10030866HCID 10030866—

Reaction Steps

The compound was prepared from [4-amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 226) and 1-methylpiperazine (Fluka) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C25H36N7O4SF2 [(M+H)+] 568.2512, observed 568.2519. CDK4 IC50=0.001; CDK1 IC50=0.039; CDK2 IC50=0.017; HCT IC90=0.274 μM.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07157455B2
Source datasetuspto-grants-2007_01
ORD IDord-9fd3c7a428204850b1def299cf6ecad3
Source noteuspto-grants-2007_01