HRID1371700

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7677

1-Piperazineethanol

C6H14N2O

结构：COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N

HCID9983584

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCN3CCN(CCO)CC3)CC2)nc1N

HCID10257967

未命名化合物

PROCEDURE

实验过程

The compound was prepared from [4-amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 226) and 1-(2-hydroxyethyl)piperazine (Aldrich) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C26H38N7O5SF2 [(M+H)+] 598.2618, observed 598.2624.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2da4d50911224ecf95b591e366d39b53
来源数据集: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07157455B2
来源说明: uspto-grants-2007_01

反应 SMILES

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[O:9])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH2:31][CH2:32]Cl)(=[O:29])=[O:28])[CH2:23][CH2:22]2)[N:3]=1.[OH:34][CH2:35][CH2:36][N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[O:9])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH2:31][CH2:32][N:40]3[CH2:41][CH2:42][N:37]([CH2:36][CH2:35][OH:34])[CH2:38][CH2:39]3)(=[O:29])=[O:28])[CH2:23][CH2:22]2)[N:3]=1