3-Chloropropanesulphonyl chloride → [4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	3-Chloropropanesulphonyl chloride	HCID 15410	—
Reactant	[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone	HCID 9997668	—
Product	[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone	HCID 10458099	—

Reaction Steps

The compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone (Example 59) and chloropropanesulfonyl chloride (Aldrich) in an analogous manner as described in Example 177. HR-MS (ES, m/z) calculated for C20H26N5O4SFCI [(M+H)+] 486.1373, observed 486.1375.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07157455B2
Source dataset	uspto-grants-2007_01
ORD ID	ord-bdbf9c67dbbf41adb2bfae31a5c84d5f
Source note	uspto-grants-2007_01