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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1371718Generated: November 2, 2026

(R)-(-)-2-Amino-1-propanol → HCID 58777620, compound

https://huagongshe.com/reaction/1371718

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-(-)-2-Amino-1-propanolHCID 80308—
Reactant[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 10458099—
ProductHCID 58777620HCID 58777620—

Reaction Steps

The compound was prepared from [4-amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone (Example 2) and (R)-2-amino-1-propanol (Aldrich) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C23H34N6O5SF [(M+H)+] 525.2290, observed 525.2294.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07157455B2
Source datasetuspto-grants-2007_01
ORD IDord-d5ef3e45e1b9491482519a3bfdc47d98
Source noteuspto-grants-2007_01