HCID 21070649, compound → HCID 21070647, compound

HRID 1371766Notes

Reaction equation

HRID 1371766 reaction equation
[N:1]([CH:4]1[CH2:9][CH2:8][N:7]([S:10]([CH3:13])(=[O:12])=[O:11])[CH2:6][CH:5]1[OH:14])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH:4]1[CH2:9][CH2:8][N:7]([S:10]([CH3:13])(=[O:12])=[O:11])[CH2:6][CH:5]1[OH:14]

Participants

4

Reactant 1

HCID 21070649HCID 21070649, compound

Product 1

HCID 21070647HCID 21070647, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The azide (300 mg, 1.36 mmol, Example 304) was dissolved in ethanol and hydrogenated at 45 psi under the catalyst of 10% palladium on carbon (30 mg) for 1 hour. The mixture was filtered and the filtrate was concentrated to give a white solid. 245 mg, 93%. The compound was used directly for the next step.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customto give a white solid

Sources & evidence

ORD record
ord-092c585777ee448096f9adf9fe732cb3
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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