HCID 21070648, compound → HCID 21070645, compound

HRID 1371771Notes

Reaction equation

HRID 1371771 reaction equation
[N:1]([CH:4]1[CH2:9][CH2:8][N:7]([S:10]([CH3:13])(=[O:12])=[O:11])[CH2:6][CH:5]1[O:14][CH3:15])=[N+]=[N-]>C(O)C.[Pd]>[CH3:13][S:10]([N:7]1[CH2:8][CH2:9][CH:4]([NH2:1])[CH:5]([O:14][CH3:15])[CH2:6]1)(=[O:12])=[O:11]

Participants

4

Reactant 1

HCID 21070648HCID 21070648, compound

Product 1

HCID 21070645HCID 21070645, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The azide (270 mg, 1.15 mmol, Example 311) in ethanol was hydrogenated at 40 psi under the catalysis of palladium on carbon for 1 hour. The mixture was filtered and the filtrate was concentrated to give an off-white solid. 230 mg, 96%. It was used directly for the next step.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customto give an off-white solid

Sources & evidence

ORD record
ord-dd01abf6e98843dabb75f0b200a57d0e
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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