5-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl- → HCID 21070588, compound

HRID 1371819Notes

Reaction equation

HRID 1371819 reaction equation
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13][CH3:14])=[N:10][CH:11]=1)=[O:5].[F:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([O:25][CH3:26])=[C:20](I)[CH:19]=1>>[NH2:15][C:7]1[C:6]([C:4]([C:20]2[CH:19]=[C:18]([F:17])[CH:23]=[C:22]([CH3:24])[C:21]=2[O:25][CH3:26])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH2:13][CH3:14])[N:8]=1

Participants

3

Reactant 2

HCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 21070505HCID 21070505, compound

Product 1

HCID 21070588HCID 21070588, compound

Procedure

The same procedure as described in Example 376 was used, starting from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide (Example 1) and 1-fluoro-3-iodo-4-methoxy-5-methyl-benzene (Example 382) to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(5-fluoro-2-methoxy-3-methyl-phenyl)-methanone. MS (M+H)+, 322.

Sources & evidence

ORD record
ord-c3b1026e2aa740ba84d182071e86ff55
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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