Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 4-(1,2-Oxazol-3-yl)aniline | HCID 23118576 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 21071328 | HCID 21071328 | 31.1% |
Reaction Steps
4-Isoxazol-3-ylphenylamine (Intermediate 5, 4 g, 24.69 mmol) was added to dichloromethane (20 ml) followed by pyridine (4.6 ml). The solution was cooled to 0° C. and benzyl chloroformate (5.27 ml, 37.02 mmol) was added drop wise. The solution was allowed to stir for 2 hours at room temperature and then concentrated under vacuum. The residue was added to 30 ml of 1:1 hexane:EtOAc mixture. The crystals were collected by filtration to yield the product (2.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07157482B2 |
|---|
| Source dataset | uspto-grants-2007_01 |
|---|
| ORD ID | ord-ad7a3b79debc45c28bbc9e54e710f215 |
|---|
| Source note | uspto-grants-2007_01 |
|---|
