HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-(2-Naphthyl)ethyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Naphthylacetonitrile | HCID 82008 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-Naphthyl)ethyl-amine | HCID 3784378 | — |
Reaction Steps
Combine naphth-2-ylacetonitrile (1.0 g, 6.0 mmol) and nickel(II) chloride hexahydrate (0.7 g, 3.0 mmol) and tetrahydrofuran (30 ml). Add dropwise borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran (24.0 ml, 24.0 mmol). After 1 hour, evaporate to give a residue. Chromatograph on silica gel eluting with 8:2 EtOAc:MeOH+2% NH4OH) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157488B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-8da498db5ffc41a08f5cbba0f86464a7 |
| Source note | uspto-grants-2007_01 |